Ageing promotes metastasis via activation of the integrated stress response - Nature

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10216-0Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoti...

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Ageing promotes metastasis via activation of the integrated stress response - Nature

Source: Nature

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10216-0Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress response, and a therapeutic opportunity in older patients is revealed.